Sep
3
BH Sales and Ocean Omega Supplier of Ocean Omega 3 Fish Oil Pet Food Supplements and Omega O’s Doggie Treats Announces Its Newest Southern Dealer Howling Acres
BH Sales and Ocean Omega announced today a new joint venture marketing campaign with Howling Acres Argentine Dogos.
Danville, Va. (PRWEB) August 17, 2005 — BH Sales AKA Ocean Omega, a Maine Based Multiple Product Distributor, announced today that it has formally established Howling Acres Argentine Dogos of Callands Virginia as its most recent dealer of Ocean Omega Fish Oil Pet Food Supplements and Omega O’s Doggie Treats. Bill Holt, Co-Owner of Ocean Omega, has enjoyed a very successful business relationship with Barbara Sanders, Proprietor of Howling Acres.
Mr. Holt is very excited about continuing his two year business relationship with Barbara Sanders; as she has utilized the fine Ocean Omega Products for her own kennel and continues to be one of Ocean Omegas most avid advocates in her work with fellow breeders and boarding kennels.
Mrs. Sanders has been a long standing championship breeder of many Nationally Recognized and Award winning Dogos, and she is considered a HIGHLY respected authority on breeding. Mrs. Sanders is very connected within the Worldwide Breeding Community and she has helped literally thousands of breeders with her valuable knowledge and is in the process of assimilating her notes to publish her first book on the subject.
BH Sales and Ocean Omega consider her accreditation and knowledge to be a vital element in their own future marketing campaigns. BH Sales and Ocean Omega are looking forward to a long term relationship with Howling Acres as Ocean Omega Promotes Good Health In ALL Pets.
The health benefits of Omega 3 Fatty Acids are well known, and the average pet owner of today has become intimately familiar with the advantages of providing such products for their pets.
Jun
25
LIPIDS AND VITAMIN E SUPPLEMENTS ON IMMUNE FUNCTIONS IN RA-PRONE MICE
Filed Under Fish Oil Research | Leave a Comment
ω-3 LIPIDS AND VITAMIN E SUPPLEMENTS ON IMMUNE FUNCTIONS IN RA-PRONE MICE
J. T. Venkatraman, Ph.D.
Department of Physical Therapy, Exercise & Nutrition Sciences
State University of New York, Buffalo, NY 14214.
ω-3 fatty acid rich-fish oil (FO) and vitamin E (vit-E) may delay the progress of certain autoimmune (AI) diseases. The present study examined the mechanism of action of ω3 and ω6 lipids and vit-E in autoimmune-prone MRL/lpr (lpr) mice. The lpr (lymphoproliferative) gene is overexpressed in these mice and they suffer from extensive lymphoproliferation, lupus-like symptoms and accelerated aging. To determine whether the effects of ω-3 lipids in autoimmune disease (AI) is linked to vit-E levels, weanling female MRL/lpr (lpr) and congenic control MRL/+/+ (+/+) mice were fed semipurified diets containing 10% corn oil (CO), 10% fish oil (FO), at two levels of vit-E (75 IU or 500 IU/kg diet) for 4m and cellular immune functions were measured. Proliferative response to lectins was significantly higher in the groups fed the high-vit E diets. The type of oil had significant effects on IL-4, IL-10, IL-12 and pro-inflammatory cytokines (TNF-α, PGE2 and TXB2) while vit-E levels had significant effects on IL-2, IFN-γ and TNF-α levels. Strain had significant effects on IL-2, IL-10, IL-12, IFN-γ, TNF-α, PGE2 and TXB2 levels IL-1 while IL-6 levels were not affected.
The level of anti-DNA antibodies in sera were significantly higher in lpr mice. FO significantly decreased IL-12, TNF-α and TXB2 levels compared to the CO fed groups. However, PGE2, IL-1, IL-2, IFN-γ, IL-4, IL-6, and IL-10 did not show differences between the two oils. The expression of IL-12 and TNF-α was significantly higher in the low vit-E groups, but not IL-1, IL-2, IFN-γ, IL-4, IL-6, IL-10 and the hormones. The levels of IL-1, IL-2, and IFN-γ were lower while IL-4, IL-6, IL-10, IL-12, and TNF-α were higher in lpr mice. The production of chemokines RANTES and MCP-1 by spleen cells was higher in MRL/lpr mice. FO decreased the production of these two chemokines by spleen cells in the MRL/lpr mice.
Autoimmune mice generally express lower activities and mRNA levels of liver antioxidant enzymes and generate higher levels of TBARS. Both FO and vit-E can significantly decrease the generation of TBARS and increase the levels of antioxidant enzymes.
In summary, data from this study suggest that adding appropriate levels of vit-E to FO diets may further enhance the beneficial effects of ω-3 lipids in delaying AI. The present study suggests that ω-3 lipids containing appropriate levels of vit-E may delay AI through modulating the levels of selected cytokines chemokines, and enzymes involved in antioxidant defense. Vit-E seems to exert selective effects on proliferative response and specific subsets and selected cytokines. (Supported by NIAMS (NIH) grant # 1R15AR/A143517).
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